Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L.

Song, Jiangli; Jones, Lindsay M; Kumar, G D Kishore; Conner, Elizabeth S; Bayeh, Liela; Chavarria, Gustavo E; Charlton-Sevcik, Amanda K; Chen, Shen-En; Chaplin, David J; Trawick, Mary Lynn; Pinney, Kevin G

Song, Jiangli; Jones, Lindsay M; Kumar, G D Kishore; Conner, Elizabeth S; Bayeh, Liela; Chavarria, Gustavo E; Charlton-Sevcik, Amanda K; Chen, Shen-En; Chaplin, David J; Trawick, Mary Lynn; Pinney, Kevin G.

Affiliation

Song J; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Jones LM; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Kumar GD; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Conner ES; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Bayeh L; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Chavarria GE; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Charlton-Sevcik AK; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Chen SE; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Chaplin DJ; OXiGENE Inc. , 701 Gateway Boulevard, Suite 210, South San Francisco, California, 94080, United States.
Trawick ML; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.
Pinney KG; Department of Chemistry and Biochemistry, Baylor University , One Bear Place #97348, Waco, Texas, 76798-7348 United States.

ACS Med Chem Lett ; 3(6): 450-3, 2012 Jun 14.

Article de En | MEDLINE | ID: mdl-24900494

Mots clés

cathepsin B; cathepsin L; inhibitor; thiochromanone; thiosemicarbazone

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: ACS Med Chem Lett Année: 2012 Type de document: Article