Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

Dail, Monique; Wong, Jason; Lawrence, Jessica; O'Connor, Daniel; Nakitandwe, Joy; Chen, Shann-Ching; Xu, Jin; Lee, Leslie B; Akagi, Keiko; Li, Qing; Aster, Jon C; Pear, Warren S; Downing, James R; Sampath, Deepak; Shannon, Kevin

Dail, Monique; Wong, Jason; Lawrence, Jessica; O'Connor, Daniel; Nakitandwe, Joy; Chen, Shann-Ching; Xu, Jin; Lee, Leslie B; Akagi, Keiko; Li, Qing; Aster, Jon C; Pear, Warren S; Downing, James R; Sampath, Deepak; Shannon, Kevin.

Affiliation

Dail M; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
Wong J; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
Lawrence J; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
O'Connor D; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
Nakitandwe J; Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Chen SC; Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Xu J; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
Lee LB; Department of Translational Oncology, Genentech Inc., South San Francisco, California 94080, USA.
Akagi K; Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA.
Li Q; Division of Haematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
Aster JC; Department of Pathology, Brigham &Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Pear WS; Abramson Family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Downing JR; Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Sampath D; Department of Translational Oncology, Genentech Inc., South San Francisco, California 94080, USA.
Shannon K; Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.

Nature ; 513(7519): 512-6, 2014 Sep 25.

Article de En | MEDLINE | ID: mdl-25043004

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sulfonamides / Résistance aux médicaments antinéoplasiques / Inhibiteurs de protéines kinases / Récepteur Notch1 / Leucémie-lymphome lymphoblastique à précurseurs T / Inhibiteurs des phosphoinositide-3 kinases / Indazoles Limites: Animals Langue: En Journal: Nature Année: 2014 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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