Influenza vaccine as prevention for cardiovascular diseases: possible molecular mechanism.
Vaccine
; 32(48): 6569-75, 2014 Nov 12.
Article
de En
| MEDLINE
| ID: mdl-25045818
ABSTRACT
Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vaccins antigrippaux
/
Maladies cardiovasculaires
/
Récepteur de la bradykinine de type B2
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Vaccine
Année:
2014
Type de document:
Article