A DNA-templated synthesis of encoded small molecules by DNA self-assembly.

Cao, Cheng; Zhao, Peng; Li, Ze; Chen, Zitian; Huang, Yanyi; Bai, Yu; Li, Xiaoyu

Cao, Cheng; Zhao, Peng; Li, Ze; Chen, Zitian; Huang, Yanyi; Bai, Yu; Li, Xiaoyu.

Affiliation

Cao C; Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing, China 100871. xiaoyuli@pku.edu.cn yu.bai@pku.edu.cn.

Chem Commun (Camb) ; 50(75): 10997-9, 2014 Sep 28.

Article de En | MEDLINE | ID: mdl-25097021

ABSTRACT

ABSTRACT

We report a novel method for the synthesis of DNA-encoded libraries without the need for discrete DNA template. Reactant DNAs self-assemble to enable chemical reactions and photo-cleavage transfers the product to the DNA terminus, making it suitable for the subsequent affinity-based selection and hit deconvolution.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: ADN Langue: En Journal: Chem Commun (Camb) Sujet du journal: QUIMICA Année: 2014 Type de document: Article

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