Mind over hormones: sex differences in associations of well-being with IGF-I, IGFBP-3 and physical activity in the KORA-Age study.
Exp Gerontol
; 59: 58-64, 2014 Nov.
Article
de En
| MEDLINE
| ID: mdl-25106099
ABSTRACT
OBJECTIVES:
A ssociations between well-being, serum levels of insulin-like growth factor 1 (IGF-I), and its primary binding protein IGFBP-3, were examined in an epidemiologic study. The influence of physical activity on the effect of hormones on well-being was considered.METHODS:
Cross-sectional data from participants of the KORA-Age study (n=985, age 64-93) was analyzed in sex-specific multivariable regressions of well-being (World Health Organization (WHO) -5) or ill-being (geriatric depression scale (GDS) -15). Models were adjusted for age, physical activity, sleep, BMI, smoking, and cognition. Adjusted WHO-5 means demonstrated the interaction between hormone quintiles with physical activity.RESULTS:
Full models indicated that increased IGFBP-3 positively associated with well-being in women (ß estimate=0.14, standard error (SE)=0.06) and less so in men (ß=0.11, SE=0.07). IGF-I associated positively with depression (ß=0.11, SE=0.06) and negatively with well-being (ß=-0.11, SE=0.06) in women. Similar but not statistically discernable effects were observed in men. Adjusted mean WHO-5 scores illustrated the positive effect of physical activity and IGFBP-3 on well-being in women only.CONCLUSIONS:
Opposite and independent associations of IGF-I and IGFBP-3 on well-being observed in women suggests neuroprotective effects of IGFBP-3 in age.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Qualité de vie
/
Facteur de croissance IGF-I
/
Caractères sexuels
/
Protéine-3 de liaison aux IGF
/
Activité motrice
Type d'étude:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limites:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Exp Gerontol
Année:
2014
Type de document:
Article
Pays d'affiliation:
Allemagne