The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.
Nat Immunol
; 15(9): 815-23, 2014 Sep.
Article
de En
| MEDLINE
| ID: mdl-25137456
ABSTRACT
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. It is now understood that the T cell repertoire is in fact broadly self-reactive, even self-centered. The strength with which a T cell reacts to self ligands and the environmental context in which this reaction occurs influence almost every aspect of T cell biology, from development to differentiation to effector function. Here we highlight recent advances and discoveries that relate to T cell self-reactivity, with a particular emphasis on T cell antigen receptor (TCR) signaling thresholds.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Récepteurs aux antigènes des cellules T
/
Lymphocytes T
/
Transduction du signal
/
Auto-immunité
/
Délétion clonale
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Nat Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2014
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique