The interleukin-10-1082A>G polymorphism and lymphoma risk: a meta-analysis.
Cancer Biomark
; 14(5): 381-8, 2014.
Article
de En
| MEDLINE
| ID: mdl-25171480
ABSTRACT
OBJECTIVE:
The Interleukin-10 (IL-10) gene polymorphism (-1082 A>G) has been linked to the risk of developing lymphoma, but the available results were inconsistent. To derive a more precise estimation, we performed a meta-analysis.METHODS:
A comprehensive search was conducted to examine all the eligible studies about IL-10-1082A>G polymorphism and lymphoma risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.RESULTS:
We included 12 studies, including 5847 cases and 6016 controls. The overall results suggested that the IL-10-1082G allele was associated with a borderline significantly increased risk of lymphoma (G vs. A OR=1.07, 95% CI=1.01-1.12; GG vs. AA OR=1.14, 95% CI=1.02-1.26; and AG+GG vs. AA OR=1.10, 95% CI=1.02-1.19). Stratifying by ethnicity (Caucasian and mixed), tumor type [non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL)], sample size (> 1000 and ⩽ 1000 subjects) and Hardy-Weinberg equilibrium (HWE) in controls, similar results were found in mixed subgroup, NHL subgroup, large studies and the subgroup conforming to HWE.CONCLUSIONS:
In conclusion, the meta-analysis suggests that the IL-10-1082A>G polymorphism is weakly associated with altered susceptibility to lymphoma. Further studies with haplotype analysis and on larger population of mixed ethnicity are warranted for a more definitive conclusion.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymorphisme génétique
/
Interleukine-10
/
Prédisposition génétique à une maladie
/
Lymphomes
Type d'étude:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Limites:
Humans
Langue:
En
Journal:
Cancer Biomark
Sujet du journal:
BIOQUIMICA
/
NEOPLASIAS
Année:
2014
Type de document:
Article
Pays d'affiliation:
Chine