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Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
Vianello, Paola; Botrugno, Oronza A; Cappa, Anna; Ciossani, Giuseppe; Dessanti, Paola; Mai, Antonello; Mattevi, Andrea; Meroni, Giuseppe; Minucci, Saverio; Thaler, Florian; Tortorici, Marcello; Trifiró, Paolo; Valente, Sergio; Villa, Manuela; Varasi, Mario; Mercurio, Ciro.
Affiliation
  • Vianello P; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address: paola.vianello@ieo.eu.
  • Botrugno OA; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Cappa A; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Ciossani G; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
  • Dessanti P; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Mai A; Pasteur Institute - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, University "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
  • Mattevi A; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy. Electronic address: andrea.mattevi@unipv.it.
  • Meroni G; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Minucci S; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy; Department of Biosciences, University of Milan, Via Celoria, 26, 20133 Milan, Italy.
  • Thaler F; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy. Electronic address: florian.thaler@ieo.eu.
  • Tortorici M; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
  • Trifiró P; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Valente S; Pasteur Institute - Cenci Bolognetti Foundation, Department of Drug Chemistry and Technologies, University "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
  • Villa M; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Varasi M; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
  • Mercurio C; Drug Discovery Unit, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
Eur J Med Chem ; 86: 352-63, 2014 Oct 30.
Article de En | MEDLINE | ID: mdl-25173853
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cyclopropanes / Antienzymes / Histone Demethylases / Monoamine oxidase Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2014 Type de document: Article Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cyclopropanes / Antienzymes / Histone Demethylases / Monoamine oxidase Limites: Humans Langue: En Journal: Eur J Med Chem Année: 2014 Type de document: Article Pays de publication: France