Bcl-2 family proteins are involved in the signal crosstalk between endoplasmic reticulum stress and mitochondrial dysfunction in tumor chemotherapy resistance.
Biomed Res Int
; 2014: 234370, 2014.
Article
de En
| MEDLINE
| ID: mdl-25177684
ABSTRACT
Tumor cells overexpress antiapoptotic proteins of the Bcl-2 (B-cell leukemia/lymphoma-2) family, which can lead to both escape from cell death and resistance to chemotherapeutic drugs. Recent studies suggest that the endoplasmic reticulum (ER) can produce proapoptotic signals, amplifying the apoptotic signaling cascade. The crosstalk between mitochondria and ER plays a decisive role in many cellular events but especially in cell death. Bcl-2 family proteins located in the ER and mitochondria can influence not only the function of the two organelles but also the interaction between them. Therefore, the Bcl-2 family of proteins may also be involved in the mechanism of tumor chemotherapy resistance by influencing crosstalk between the ER and mitochondria. In this review we will briefly discuss evidence to support this concept.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Résistance aux médicaments antinéoplasiques
/
Protéines proto-oncogènes c-bcl-2
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Interactions entre récepteurs
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Réticulum endoplasmique
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Mitochondries
/
Tumeurs
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biomed Res Int
Année:
2014
Type de document:
Article
Pays d'affiliation:
Chine