Attenuated salivary cortisol response after exercise test in children with asthma.
J Pediatr Endocrinol Metab
; 28(3-4): 359-65, 2015 Mar.
Article
de En
| MEDLINE
| ID: mdl-25210752
ABSTRACT
OBJECTIVE:
The clinical relevance of lower basal cortisol levels in children with asthma is unclear. We compared the salivary cortisol response after a standardized exercise test in children with asthma versus the salivary cortisol response in healthy children.METHODS:
Nineteen prepubertal children with asthma and 20 prepubertal healthy children performed a standardized exercise test twice. Salivary cortisol levels were determined before exercise and immediately and 15 min after exercise. Morning salivary cortisol levels were determined from saliva collected at home.RESULTS:
Salivary cortisol levels increased in 84.2% of the healthy children compared to 35.0% in children with asthma after the 20-m shuttle-run test. Median increase in salivary cortisol levels was 200.3% [95% confidence interval (CI), 141.8-346.1] in healthy children compared to 89.8% (95% CI, 56.9-181.6) in children with asthma. The response was not related to the morning salivary cortisol level or maintenance dose of inhaled corticosteroids. The mean time to exhaustion of both shuttle-run tests was significantly shorter in children with asthma (mean difference 1.4 min; 95% CI, 0.7-2.3). None of the children had to stop because of dyspnea.CONCLUSION:
Our study demonstrates that children with asthma using a maintenance dose of inhaled corticosteroids (ICS) have an attenuated salivary cortisol response compared with healthy children.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Asthme
/
Salive
/
Hydrocortisone
/
Exercice physique
Type d'étude:
Clinical_trials
Limites:
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Pediatr Endocrinol Metab
Sujet du journal:
ENDOCRINOLOGIA
/
PEDIATRIA
Année:
2015
Type de document:
Article