Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.

Maloney, Janice A; Bainbridge, Travis; Gustafson, Amy; Zhang, Shuo; Kyauk, Roxanne; Steiner, Pascal; van der Brug, Marcel; Liu, Yichin; Ernst, James A; Watts, Ryan J; Atwal, Jasvinder K

Maloney, Janice A; Bainbridge, Travis; Gustafson, Amy; Zhang, Shuo; Kyauk, Roxanne; Steiner, Pascal; van der Brug, Marcel; Liu, Yichin; Ernst, James A; Watts, Ryan J; Atwal, Jasvinder K.

Affiliation

Maloney JA; From the Departments of Neuroscience.
Bainbridge T; Protein Chemistry.
Gustafson A; Biochemical and Cellular Pharmacology, and.
Zhang S; From the Departments of Neuroscience.
Kyauk R; From the Departments of Neuroscience.
Steiner P; From the Departments of Neuroscience.
van der Brug M; ITGR Diagnostics Discovery, Genentech, Inc., South San Francisco, California 94080.
Liu Y; Biochemical and Cellular Pharmacology, and.
Ernst JA; From the Departments of Neuroscience, Protein Chemistry, jernst@gene.com.
Watts RJ; From the Departments of Neuroscience, rwatts@gene.com.
Atwal JK; From the Departments of Neuroscience, jatwal@gene.com.

J Biol Chem ; 289(45): 30990-1000, 2014 Nov 07.

Article de En | MEDLINE | ID: mdl-25253696

Sujet(s)
Mots clés

Alzheimer Disease; Amyloid Precursor Protein (APP); Amyloid-ß (AB); Neurobiology; Proteolytic Enzyme; ß-Secretase 1 (BACE1)

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Précurseur de la protéine bêta-amyloïde / Maladie d'Alzheimer Type d'étude: Observational_studies / Prognostic_studies / Risk_factors_studies Limites: Animals / Humans Langue: En Journal: J Biol Chem Année: 2014 Type de document: Article Pays de publication: États-Unis d'Amérique

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