Lead identification to clinical candidate selection: drugs for Chagas disease.

Neitz, R Jeffrey; Chen, Steven; Supek, Frantisek; Yeh, Vince; Kellar, Danielle; Gut, Jiri; Bryant, Clifford; Gallardo-Godoy, Alejandra; Molteni, Valentina; Roach, Steven L; Khare, Shilpi; Stinson, Monique; Chatterjee, Arnab K; Robertson, Stephanie; Renslo, Adam R; Arkin, Michelle; Glynne, Richard; McKerrow, James; Siqueira-Neto, Jair L

Neitz, R Jeffrey; Chen, Steven; Supek, Frantisek; Yeh, Vince; Kellar, Danielle; Gut, Jiri; Bryant, Clifford; Gallardo-Godoy, Alejandra; Molteni, Valentina; Roach, Steven L; Khare, Shilpi; Stinson, Monique; Chatterjee, Arnab K; Robertson, Stephanie; Renslo, Adam R; Arkin, Michelle; Glynne, Richard; McKerrow, James; Siqueira-Neto, Jair L.

Affiliation

Neitz RJ; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Chen S; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Supek F; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Yeh V; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Kellar D; Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA Five Prime Therapeutics, San Francisco, CA, USA.
Gut J; Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA.
Bryant C; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Gallardo-Godoy A; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Molteni V; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Roach SL; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA Dart Neuroscience, San Diego, CA, USA.
Khare S; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Stinson M; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
Chatterjee AK; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA California Institute for Biomedical Research (Calibr), San Diego, CA, USA.
Robertson S; Innovation, Technology, and Alliances, University of California, San Francisco, CA, USA.
Renslo AR; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Arkin M; Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.
Glynne R; Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA.
McKerrow J; Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, CA, USA.
Siqueira-Neto JL; Center for Discovery and Innovation in Parasitic Diseases, University of California, San Francisco, CA, USA Department of Pathology, University of California, San Francisco, CA, USA Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, CA, USA jairlage@gmail.com.

J Biomol Screen ; 20(1): 101-11, 2015 Jan.

Article de En | MEDLINE | ID: mdl-25281737

Sujet(s)
Mots clés

Chagas disease; cell-based assays; drug discovery; high-content screening; high-throughput screening

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Trypanocides / Trypanosoma cruzi / Découverte de médicament / Tests de criblage à haut débit Type d'étude: Diagnostic_studies Limites: Animals / Humans Langue: En Journal: J Biomol Screen Sujet du journal: BIOLOGIA MOLECULAR Année: 2015 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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