miR-466 is putative negative regulator of Coxsackie virus and Adenovirus Receptor.
FEBS Lett
; 589(2): 246-54, 2015 Jan 16.
Article
de En
| MEDLINE
| ID: mdl-25497012
ABSTRACT
This study aimed at elucidating how Coxsackie B virus (CVB) perturbs the host's microRNA (miRNA) regulatory pathways that lead to antiviral events. The results of miRNA profiling in rat pancreatic cells infection models revealed that rat rno-miR-466d was up-regulated in CVB infection. Furthermore, in silico studies showed that Coxsackie virus and Adenovirus Receptor (CAR), a cellular receptor, was one of the rno-miR-466d targets involved in viral entry. Subsequent experiments also proved that both the rno-miR-466d and the human hsa-miR-466, which are orthologs of the miR-467 gene family, could effectively down-regulate the levels of rat and human CAR protein expression, respectively.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Entérovirus humain B
/
MicroARN
/
Protéine membranaire apparentée au récepteur des coxsackievirus et adénovirus
Limites:
Animals
/
Humans
Langue:
En
Journal:
FEBS Lett
Année:
2015
Type de document:
Article
Pays d'affiliation:
Hong Kong