Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex.
Neurobiol Dis
; 74: 359-76, 2015 Feb.
Article
de En
| MEDLINE
| ID: mdl-25500340
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (SALS) and probably associated to a multifactorial etiology. Currently there is no cure or prevention for ALS. A prerequisite to formulating therapeutic strategies is gaining understanding of its etio-pathogenic mechanisms. In this study we analyzed whole-genome expression profiles of 41 motor cortex samples of control (10) and sporadic ALS (31) patients. Unsupervised hierarchical clustering was able to separate control from SALS patients. In addition, SALS patients were subdivided in two different groups that were associated to different deregulated pathways and genes, some of which were previously associated to familiar ALS. These experiments are the first to highlight the genomic heterogeneity of sporadic ALS and reveal new clues to its pathogenesis and potential therapeutic targets.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Analyse de regroupements
/
Analyse de profil d'expression de gènes
/
Apprentissage machine non supervisé
/
Sclérose latérale amyotrophique
/
Cortex moteur
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Neurobiol Dis
Sujet du journal:
NEUROLOGIA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Pays-Bas