α-thalassemia-associated hydrops fetalis: A rare cause of thyrotoxic cardiomyopathy.
J Obstet Gynaecol Res
; 41(6): 967-70, 2015 Jun.
Article
de En
| MEDLINE
| ID: mdl-25510540
ABSTRACT
α°-thalassemia is a well-known cause of hydrops fetalis in South-East Asia and can be detected in utero. We report a very rare case of thyrotoxic cardiomyopathy associated with hyperplacentosis secondary to α°-thalassemia-associated hydrops fetalis. A 22-year-old primigravida with microcytic anemia presented at 27 weeks' gestation with pre-eclampsia, hyperthyroidism and cardiac failure. Serum ß-human chorionic gonadotrophin was markedly elevated and abdominal ultrasound revealed severe hydropic features and enlarged placenta. Serum ß-human chorionic gonadotrophin, cardiac function and thyroid function tests normalized after she delivered a macerated stillbirth. Histopathology of the placenta showed hyperplacentosis. Blood DNA analysis revealed that both patient and husband have the α°-thalassemia trait. This case illustrates a very atypical presentation of α°-thalassemia-associated hydrops fetalis and the importance of early prenatal diagnosis of α-thalassemia in women of relevant ethnic origin with microcytic anemia so that appropriate genetic counseling can be provided to reduce maternal morbidity and the incidence of hydrops fetalis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Complications de la grossesse
/
Thyréotoxicose
/
Anasarque foetoplacentaire
/
Alpha-Thalassémie
/
Cardiomyopathies
Type d'étude:
Diagnostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Pregnancy
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
J Obstet Gynaecol Res
Sujet du journal:
GINECOLOGIA
/
OBSTETRICIA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Malaisie