GABAA &#945;5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.

de Lucas, A Garcia; Ahring, P K; Larsen, J S; Rivera-Arconada, I; Lopez-Garcia, J A; Mirza, N R; Munro, G

GABAA α5 subunit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.

de Lucas, A Garcia; Ahring, P K; Larsen, J S; Rivera-Arconada, I; Lopez-Garcia, J A; Mirza, N R; Munro, G.

Affiliation

de Lucas AG; Department of Physiology, University of Alcala, Alcala de Henares, Madrid, Spain.
Ahring PK; Saniona AB, Baltorpvej 154, Ballerup DK-2750, Denmark; Faculty of Pharmacy, The University of Sydney, Australia.
Larsen JS; Saniona AB, Baltorpvej 154, Ballerup DK-2750, Denmark.
Rivera-Arconada I; Department of Physiology, University of Alcala, Alcala de Henares, Madrid, Spain.
Lopez-Garcia JA; Department of Physiology, University of Alcala, Alcala de Henares, Madrid, Spain.
Mirza NR; Saniona AB, Baltorpvej 154, Ballerup DK-2750, Denmark.
Munro G; Department of Pharmacology, NeuroSearch A/S, Pederstrupvej 93, Ballerup DK-2750, Denmark. Electronic address: gmun@lundbeck.com.

Biochem Pharmacol ; 93(3): 370-9, 2015 Feb 01.

Article de En | MEDLINE | ID: mdl-25542996

Sujet(s)
Mots clés

Analgesia; Central sensitization; Hyperalgesia; Pain; Spinal inhibition; Wind-up

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridines / Racines des nerfs spinaux / Benzimidazoles / Mesure de la douleur / Récepteurs GABA-A / Modulateurs GABA Limites: Animals / Female / Humans / Male Langue: En Journal: Biochem Pharmacol Année: 2015 Type de document: Article Pays d'affiliation: Espagne Pays de publication: Royaume-Uni

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