Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells.

Chen, Lu; Du-Cuny, Lei; Moses, Sylvestor; Dumas, Sabrina; Song, Zuohe; Rezaeian, Abdol Hossein; Lin, Hui-Kuan; Meuillet, Emmanuelle J; Zhang, Shuxing

Chen, Lu; Du-Cuny, Lei; Moses, Sylvestor; Dumas, Sabrina; Song, Zuohe; Rezaeian, Abdol Hossein; Lin, Hui-Kuan; Meuillet, Emmanuelle J; Zhang, Shuxing.

Affiliation

Chen L; Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.
Du-Cuny L; Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.
Moses S; Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America.
Dumas S; Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America.
Song Z; Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America.
Rezaeian AH; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.
Lin HK; Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America.
Meuillet EJ; Departments of Nutritional Sciences and Molecular and Cellular Biology, the University of Arizona Cancer Center, Tucson, Arizona, United States of America.
Zhang S; Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.

PLoS Comput Biol ; 11(1): e1004021, 2015 Jan.

Article de En | MEDLINE | ID: mdl-25569504

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Phosphoprotéines / Tumeurs du sein / Protéines du sang / Protéines adaptatrices de la transduction du signal / Antinéoplasiques Type d'étude: Prognostic_studies Limites: Female / Humans Langue: En Journal: PLoS Comput Biol Sujet du journal: BIOLOGIA / INFORMATICA MEDICA Année: 2015 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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