Relationship between T-cell HLA-DR expression and intravenous immunoglobulin treatment response in Kawasaki disease.
Pediatr Res
; 77(4): 536-40, 2015 Apr.
Article
de En
| MEDLINE
| ID: mdl-25580740
ABSTRACT
BACKGROUND:
Kawasaki disease (KD) is an acute febrile illness associated with the development of vasculitis. Administration of intravenous immunoglobulin (IVIG) is the standard treatment for KD. However, IVIG treatment is not effective in approximately 15% of children with KD. Some reports have presented evidence of immunological responses in IVIG-resistant KD patients. We assessed the possibility that T-cell activation is a contributing mechanism underlying this phenomenon.METHODS:
We analyzed human leukocyte antigen-DR (HLA-DR) expression on peripheral blood CD4+ and CD8+ T cells in 82 children with KD who were admitted to the hospital between October 2007 and February 2012. We compared the percentages of HLA-DR+ T cells among the CD4+ T-cell and CD8+ T-cell populations for the IVIG-effective and IVIG-resistant groups.RESULTS:
Among the 82 subjects, 51 had IVIG-effective KD and 31 children had IVIG-resistant KD. The percentages of HLA-DR+ T cells among the CD4+ T-cell and CD8+ T-cell populations in the IVIG-effective group were significantly lower than those in the IVIG-resistant group.CONCLUSION:
Our results suggest that increased T-cell HLA-DR expression is associated with IVIG resistance in KD patients, indicating that HLA-DR expression would be a useful tool for predicting IVIG responsiveness during KD pathogenesis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antigènes HLA-DR
/
Régulation de l'expression des gènes
/
Immunoglobulines par voie veineuse
/
Maladie de Kawasaki
Type d'étude:
Prognostic_studies
Limites:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Langue:
En
Journal:
Pediatr Res
Année:
2015
Type de document:
Article
Pays d'affiliation:
Japon