Chronic infection. Hidden costs of infection: chronic malaria accelerates telomere degradation and senescence in wild birds.
Science
; 347(6220): 436-8, 2015 Jan 23.
Article
de En
| MEDLINE
| ID: mdl-25613889
ABSTRACT
Recovery from infection is not always complete, and mild chronic infection may persist. Although the direct costs of such infections are apparently small, the potential for any long-term effects on Darwinian fitness is poorly understood. In a wild population of great reed warblers, we found that low-level chronic malaria infection reduced life span as well as the lifetime number and quality of offspring. These delayed fitness effects of malaria appear to be mediated by telomere degradation, a result supported by controlled infection experiments on birds in captivity. The results of this study imply that chronic infection may be causing a series of small adverse effects that accumulate and eventually impair phenotypic quality and Darwinian fitness.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Oiseaux chanteurs
/
Aptitude génétique
/
Homéostasie des télomères
/
Paludisme
/
Paludisme aviaire
Type d'étude:
Health_economic_evaluation
Limites:
Animals
Langue:
En
Journal:
Science
Année:
2015
Type de document:
Article
Pays d'affiliation:
Suède