A novel CRTH2 antagonist: Single- and multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-453859 in healthy subjects.

Géhin, Martine; Strasser, Daniel S; Zisowsky, Jochen; Farine, Hervé; Groenen, Peter M A; Dingemanse, Jasper; Sidharta, Patricia N

Géhin, Martine; Strasser, Daniel S; Zisowsky, Jochen; Farine, Hervé; Groenen, Peter M A; Dingemanse, Jasper; Sidharta, Patricia N.

Affiliation

Géhin M; Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Strasser DS; Department of Translational Science, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Zisowsky J; Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Farine H; Department of Translational Science, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Groenen PM; Department of Translational Science, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Dingemanse J; Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.
Sidharta PN; Department of Clinical Pharmacology, Actelion Pharmaceuticals Ltd, Allschwil, Switzerland.

J Clin Pharmacol ; 55(7): 787-97, 2015 Jul.

Article de En | MEDLINE | ID: mdl-25655470

Sujet(s)
Mots clés

ACT-453859; CRTH2; entry-into-humans study; pharmacokinetics; receptor internalization

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Carbazoles / Récepteur prostaglandine / Récepteurs immunologiques / Acétates Type d'étude: Clinical_trials Limites: Adolescent / Adult / Female / Humans / Male / Middle aged Langue: En Journal: J Clin Pharmacol Année: 2015 Type de document: Article Pays d'affiliation: Suisse Pays de publication: Royaume-Uni

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