Synthesis, antioxidant and anti-microbial properties of two organoselenium compounds.
Pak J Pharm Sci
; 28(2): 611-6, 2015 Mar.
Article
de En
| MEDLINE
| ID: mdl-25730792
ABSTRACT
The aim of this study is synthesis of two different series of organoselenium compounds and available in vitro antioxidant and antimicrobial properties of these synthetic compounds. The synthetic compounds were identified by (1)H-NMR (300 MHz), (13)C-NMR (75.5 MHz), FT-IR spectroscopic techniques and micro analysis. Antioxidant properties of two synthetic organoselenium compounds were determined by 1,1- diphenyl-2-picrylhydrazyl (DPPH) radical method, reducing power assay and ß-carotene bleaching method as in vitro. Antimicrobial effects of samples were assessed by the agar dilution procedure and using gram positive and gram-negative bacteria and yeast strains. Although 1,3-di-p-methoxybenzylpyrimidine-2-selenone showed better antiradical activity in DPPH test and higher protective activity on ß-carotene, 1-isopropyl-3-methylbenzimidazole-2-selenone was found to be better in reducing power and antimicrobial activity.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Composés organiques du sélénium
/
Anti-infectieux
/
Antioxydants
Langue:
En
Journal:
Pak J Pharm Sci
Sujet du journal:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Turquie