Primary cutaneous cribriform carcinoma: report of six cases with clinicopathologic data and immunohistochemical profile.
J Cutan Pathol
; 42(6): 379-87, 2015 Jun.
Article
de En
| MEDLINE
| ID: mdl-25732813
ABSTRACT
BACKGROUND:
Primary cutaneous cribriform carcinoma (PCCC) is a rare and under-recognized variant of sweat gland carcinoma, characterized by anastomosing tubules and solid nests producing a sieve-like appearance.METHODS:
Six cases of PCCC were clinically, histopathologically and immunophenotypically studied.RESULTS:
All cases showed an unencapsulated, nodular dermal tumor composed of solid and cribriform nests, cords and tubules embedded within a desmoplastic stroma. Some tubules showed micropapillary projections reminiscent of tubular adenoma, and intraluminal thin bridges resembling adenomatoid tumor. One case showed a predominantly solid component. Only two cases showed very focal decapitation secretion. Tumor cells expressed CK7, CK5/6, EMA, CEA, S-100, BerEP4 and c-kit and were negative for cytokeratin 20, estrogen receptor/progesterone receptor (ER/PR), androgen receptor and GCDFP-15. Calponin, p63 and smooth muscle actin (SMA) showed absence of a myoepithelial layer.CONCLUSIONS:
Contrary to the original reports, our series shows that PCCC may be predominantly solid with only a minor cribriform component, and expresses c-kit and S-100 which may potentially lead to the misdiagnosis of adenoid cystic carcinoma. Immunohistochemical stains may aid in distinction from tubular adenoma. Current data suggest a favorable outcome, as metastatic disease has not been reported to date.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs cutanées
/
Tumeurs des glandes sudoripares
/
Adénocarcinome
/
Carcinome adénoïde kystique
Type d'étude:
Diagnostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Cutan Pathol
Année:
2015
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique