Meta-analysis: is combination of tetracycline and amoxicillin suitable for Helicobacter pylori infection?
World J Gastroenterol
; 21(8): 2522-33, 2015 Feb 28.
Article
de En
| MEDLINE
| ID: mdl-25741163
ABSTRACT
AIM:
To access the efficacy of combination with amoxicillin and tetracycline for eradication of Helicobacter pylori (H. pylori), thus providing clinical practice guidelines.METHODS:
PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Science Citation Index, China National Knowledge Infrastructure, Wanfang, and Chinese Biomedical Literature databases and abstract books of major European, American, and Asian gastroenterological meetings were searched. All clinical trials that examined the efficacy of H. pylori eradication therapies and included both tetracycline and amoxicillin in one study arm were selected for this systematic review and meta-analysis. Statistical analysis was performed with Comprehensive Meta-Analysis Software (Version 2). Subgroup, meta-regression, and sensitivity analyses were also carried out.RESULTS:
Thirty-three studies met the inclusion criteria. The pooled odds ratio (OR) was 0.90 (95%CI 0.42-1.78) for quadruple therapy with amoxicillin and tetracycline vs other quadruple regimens, and total eradication rates were 78.1% by intention-to-treat (ITT) and 84.5% by per-protocol (PP) analyses in the experimental groups. The pooled eradication rates of 14-d quadruple regimens with a combination of amoxicillin and tetracycline were 82.3% by ITT and 89.0% by PP, and those of 10-d regimens were 84.6% by ITT and 93.7% by PP. The OR by ITT were 1.21 (95%CI 0.64-2.28) for triple regimens with amoxicillin and tetracycline vs other regimens and 1.81 (95%CI 1.37-2.41) for sequential treatment with amoxicillin and tetracycline vs other regimens, respectively.CONCLUSION:
The effectiveness of regimens employing amoxicillin and tetracycline for H. pylori eradication may be not inferior to other regimens, but further study should be necessary.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tétracycline
/
Helicobacter pylori
/
Infections à Helicobacter
/
Amoxicilline
/
Antibactériens
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Guideline
/
Systematic_reviews
Limites:
Humans
Langue:
En
Journal:
World J Gastroenterol
Sujet du journal:
GASTROENTEROLOGIA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Chine