VX-509 (decernotinib) is a potent and selective janus kinase 3 inhibitor that attenuates inflammation in animal models of autoimmune disease.

Mahajan, Sudipta; Hogan, James K; Shlyakhter, Dina; Oh, Luke; Salituro, Francesco G; Farmer, Luc; Hoock, Thomas C

Mahajan, Sudipta; Hogan, James K; Shlyakhter, Dina; Oh, Luke; Salituro, Francesco G; Farmer, Luc; Hoock, Thomas C.

Affiliation

Mahajan S; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Hogan JK; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Shlyakhter D; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Oh L; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Salituro FG; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Farmer L; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.).
Hoock TC; Departments of Integrated Biology and Chemistry, Vertex Pharmaceuticals, Boston, Massachusetts (S.M., J.K.H., D.S., L.F., T.C.H.); Sage Therapeutics, Cambridge, Massachusetts (F.G.S.); and Mallinckrodt Pharmaceuticals, Ellicott City, Maryland (L.O.) Thomas_hoock@vrtx.com.

J Pharmacol Exp Ther ; 353(2): 405-14, 2015 May.

Article de En | MEDLINE | ID: mdl-25762693

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies auto-immunes / Valine / Inhibiteurs de protéines kinases / Janus kinase 3 / Composés hétérobicycliques Type d'étude: Prognostic_studies Limites: Animals / Female / Humans / Male Langue: En Journal: J Pharmacol Exp Ther Année: 2015 Type de document: Article Pays de publication: États-Unis d'Amérique

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