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Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts.
Valente, Sergio; Rodriguez, Veronica; Mercurio, Ciro; Vianello, Paola; Saponara, Bruna; Cirilli, Roberto; Ciossani, Giuseppe; Labella, Donatella; Marrocco, Biagina; Monaldi, Daria; Ruoppolo, Giovanni; Tilset, Mats; Botrugno, Oronza A; Dessanti, Paola; Minucci, Saverio; Mattevi, Andrea; Varasi, Mario; Mai, Antonello.
Affiliation
  • Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Rodriguez V; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Mercurio C; Genextra Group, DAC s.r.l. Via Adamello 16, 20139 Milano, Italy.
  • Vianello P; Dipartimento di Oncologia Sperimentale, IEO - European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy.
  • Saponara B; Italian National Institute of Health, Department of Therapeutic Research and Medicines Evaluation, Via Regina Elena 299, 00161 Roma, Italy.
  • Cirilli R; Italian National Institute of Health, Department of Therapeutic Research and Medicines Evaluation, Via Regina Elena 299, 00161 Roma, Italy.
  • Ciossani G; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
  • Labella D; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Marrocco B; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Monaldi D; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Ruoppolo G; Department of Sense Organs, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy.
  • Tilset M; Centre of Theoretical and Computational Chemistry (CTCC), Department of Chemistry, P.O. Box 1033, Blindern, N-0315 Oslo, Norway.
  • Botrugno OA; Dipartimento di Oncologia Sperimentale, IEO - European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy.
  • Dessanti P; Dipartimento di Oncologia Sperimentale, IEO - European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy.
  • Minucci S; Dipartimento di Oncologia Sperimentale, IEO - European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy; Department of Biosciences, University of Milan, 20100 Milan, Italy.
  • Mattevi A; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy.
  • Varasi M; Dipartimento di Oncologia Sperimentale, IEO - European Institute of Oncology, Via Adamello 16, 20139 Milano, Italy.
  • Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy; Pasteur Institute - Cenci Bolognetti Foundation, Sapienza University of Roma, P.le A. Moro 5, 00185 Roma, Italy. Electronic address: antonello.mai@uniroma1.it.
Eur J Med Chem ; 94: 163-74, 2015 Apr 13.
Article de En | MEDLINE | ID: mdl-25768700
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tranylcypromine / Leucémies / Antienzymes / Histone Demethylases Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2015 Type de document: Article Pays d'affiliation: Italie Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tranylcypromine / Leucémies / Antienzymes / Histone Demethylases Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2015 Type de document: Article Pays d'affiliation: Italie Pays de publication: France