Serum creatinine level: a supplemental index to distinguish Duchenne muscular dystrophy from Becker muscular dystrophy.
Dis Markers
; 2015: 141856, 2015.
Article
de En
| MEDLINE
| ID: mdl-25852218
ABSTRACT
BACKGROUND:
To improve assessment of dystrophinopathy, the aim of this study was to identify whether serum creatinine (Crn) level reflects disease severity.METHODS:
Biochemical, Vignos score, and genetic data were collected on 212 boys with dystrophinopathy.RESULTS:
Serum Crn level had a strong inverse correlation with Vignos score by simple correlation (r = -0.793) and partial correlation analysis after adjustment for age, height, and weight (r = -0.791; both P < 0.01). Serum Crn level was significantly higher in patients with in-frame than out-of-frame mutations (Z = -4.716, P < 0.01) and in Becker muscular dystrophy (BMD) patients than Duchenne muscular dystrophy (DMD) patients at ages 4, 5, 7, and 9 yr (all P < 0.0125). After adjusting for age, height, and weight, BMD patients still had a significantly higher serum Crn level than DMD patients (ß = 7.140, t = 6.277, P < 0.01).CONCLUSIONS:
Serum Crn level reflected disease severity and may serve as a supplemental index to distinguish DMD from BMD in clinical practice.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Myopathie de Duchenne
/
Créatinine
Type d'étude:
Prognostic_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Male
Langue:
En
Journal:
Dis Markers
Sujet du journal:
BIOQUIMICA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Chine