Development of curative therapies for Ewing sarcomas by interdisciplinary cooperative groups in Europe.

Bölling, T; Braun-Munzinger, G; Burdach, S; Calaminus, G; Craft, A; Delattre, O; Deley, M-C L; Dirksen, U; Dockhorn-Dworniczak, B; Dunst, J; Engel, S; Faldum, A; Fröhlich, B; Gadner, H; Göbel, U; Gosheger, G; Hardes, J; Hawkins, D S; Hjorth, L; Hoffmann, C; Kovar, H; Kruseova, J; Ladenstein, R; Leuschner, I; Lewis, I J; Oberlin, O; Paulussen, M; Potratz, J; Ranft, A; Rössig, C; Rübe, C; Sauer, R; Schober, O; Schuck, A; Timmermann, B; Tirode, F; van den Berg, H; van Valen, F; Vieth, V; Willich, N; Winkelmann, W; Whelan, J; Womer, R B

Bölling, T; Braun-Munzinger, G; Burdach, S; Calaminus, G; Craft, A; Delattre, O; Deley, M-C L; Dirksen, U; Dockhorn-Dworniczak, B; Dunst, J; Engel, S; Faldum, A; Fröhlich, B; Gadner, H; Göbel, U; Gosheger, G; Hardes, J; Hawkins, D S; Hjorth, L; Hoffmann, C; Kovar, H; Kruseova, J; Ladenstein, R; Leuschner, I; Lewis, I J; Oberlin, O; Paulussen, M; Potratz, J; Ranft, A; Rössig, C; Rübe, C; Sauer, R; Schober, O; Schuck, A; Timmermann, B; Tirode, F; van den Berg, H; van Valen, F; Vieth, V; Willich, N; Winkelmann, W; Whelan, J; Womer, R B.

Affiliation

Bölling T; Department Osnabrueck, Center for Radiotherapy Rheine-Osnabrueck, Osnabrueck, Germany.
Braun-Munzinger G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Burdach S; Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Calaminus G; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Craft A; Royal Victoria Infirmary, Newcastle, United Kingdom.
Delattre O; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
Deley MC; Université Paris-Sud, Le Kremlin-Bicêtre, and Gustave Roussy Institute, Villejuif, France.
Dirksen U; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Dockhorn-Dworniczak B; Zentrum für Pathologie Kempten-Allgäu, Kempten, Germany.
Dunst J; Department of Radiation Oncology, University of Luebeck and University Medical Center Schleswig-Holstein, Campus Luebeck, Germany.
Engel S; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Faldum A; Institute of Biostatistics and Clinical Research, University of Muenster, Muenster, Germany.
Fröhlich B; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Gadner H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Göbel U; Clinic of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine-University, Duesseldorf, Germany.
Gosheger G; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hardes J; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Hawkins DS; Seattle Children's Hospital and Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
Hjorth L; Skåne University Hospital, Lund University, Lund, Sweden.
Hoffmann C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Kovar H; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Kruseova J; Department of Paediatric Haematology and Oncology Charles University, 2nd School of Medicine, Prague, Czech Republic.
Ladenstein R; St. Anna Kinderkrebsforschung e.V., Children's Cancer Research Institute, and Department of Pediatrics, Medical University Vienna.
Leuschner I; Kiel Paediatric Tumor Registry, Department of Paediatric Pathology, Christian-Albrechts-University Kiel, Kiel, Germany.
Lewis IJ; Alder Hey Children's National Health Service Foundation Trust, Liverpool, UK.
Oberlin O; Gustave Roussy Institute, Villejuif, France.
Paulussen M; Vestische Kinder-und Jugendklinik Datteln, Witten/Herdecke University, Datteln, Germany.
Potratz J; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Ranft A; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rössig C; Pediatric Hematology and Oncology Muenster, University Children's Hospital Muenster, Germany.
Rübe C; Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center, Homburg, Germany.
Sauer R; Department of Radiation Therapy, University of Erlangen, Erlangen, Germany.
Schober O; Department of Nuclear Medicine, University of Münster, Münster, Germany.
Schuck A; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Timmermann B; Clinic for Particle Therapy, West German Proton Therapy Center Essen, West German Cancer Center, University Hospital Essen.
Tirode F; Inserm U830, Laboratory of Genetics and Biology of Cancers, Institut Curie, Paris, France.
van den Berg H; Emma Children Hospital AMC, University of Amsterdam, Amsterdam, the Netherlands.
van Valen F; Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany.
Vieth V; Department of Clinical Radiology, University Hospital Muenster, Muenster, Germany.
Willich N; Department of Radiotherapy, University Hospital Muenster, Muenster, Germany.
Winkelmann W; Department of Orthopedic Surgery, University Hospital Muenster, Muenster, Germany.
Whelan J; NIHR University College London Hospitals Biomedical Research Centre, London, UK.
Womer RB; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Klin Padiatr ; 227(3): 108-15, 2015 May.

Article de En | MEDLINE | ID: mdl-25985445

ABSTRACT

ABSTRACT

Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Sarcome d'Ewing / Tumeurs des tissus mous / Tumeurs osseuses / Comportement coopératif / Communication interdisciplinaire Limites: Child / Humans Langue: En Journal: Klin Padiatr Année: 2015 Type de document: Article Pays d'affiliation: Allemagne

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