In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes.
Antimicrob Agents Chemother
; 59(8): 5032-5, 2015 Aug.
Article
de En
| MEDLINE
| ID: mdl-26014947
ABSTRACT
Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Spiranes
/
Leishmaniose
/
Leishmania infantum
/
Artémisinines
/
Composés hétéromonocycliques
/
Antiparasitaires
Limites:
Humans
Langue:
En
Journal:
Antimicrob Agents Chemother
Année:
2015
Type de document:
Article