Organocatalytic, Enantioselective Synthesis of 1- and 3-Substituted Isochromans via Intramolecular Oxa-Michael Reaction of Alkoxyboronate: Synthesis of (+)-Sonepiprazole.
J Org Chem
; 80(14): 7008-18, 2015 Jul 17.
Article
de En
| MEDLINE
| ID: mdl-26102523
ABSTRACT
The enantioselective oxa-Michael reaction of alkoxyboronate strategy was demonstrated to provide a new and practical route to enantioriched 1- and 3-substituted isochromans using a chiral bifunctional organocatalyst. Furthermore, this methodology was extended to the enantioselective synthesis of (+)-sonepiprazole, a dopamine receptor antagonist.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pipérazines
/
Sulfonamides
/
Acides boroniques
/
Chromanes
Langue:
En
Journal:
J Org Chem
Année:
2015
Type de document:
Article
Pays d'affiliation:
Inde