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Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.
Xu, Li-Li; Zhu, Jun-Feng; Xu, Xiao-Li; Zhu, Jie; Li, Li; Xi, Mei-Yang; Jiang, Zheng-Yu; Zhang, Ming-Ye; Liu, Fang; Lu, Meng-chen; Bao, Qi-Chao; Li, Qi; Zhang, Chao; Wei, Jin-Lian; Zhang, Xiao-Jin; Zhang, Lian-Shan; You, Qi-Dong; Sun, Hao-Peng.
Affiliation
  • Xu LL; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Zhu JF; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Xu XL; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Zhu J; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Li L; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Xi MY; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Jiang ZY; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang MY; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Liu F; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Lu MC; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Bao QC; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Li Q; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang C; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Wei JL; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang XJ; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Zhang LS; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  • You QD; †Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China.
  • Sun HP; ‡State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
J Med Chem ; 58(14): 5419-36, 2015 Jul 23.
Article de En | MEDLINE | ID: mdl-26111355
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Oxadiazoles / Conception de médicament / Facteur-2 apparenté à NF-E2 / Anti-inflammatoires Type d'étude: Diagnostic_studies / Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2015 Type de document: Article Pays d'affiliation: Chine
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Oxadiazoles / Conception de médicament / Facteur-2 apparenté à NF-E2 / Anti-inflammatoires Type d'étude: Diagnostic_studies / Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2015 Type de document: Article Pays d'affiliation: Chine