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Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
Kern, Gunther; Palmer, Tiffany; Ehmann, David E; Shapiro, Adam B; Andrews, Beth; Basarab, Gregory S; Doig, Peter; Fan, Jun; Gao, Ning; Mills, Scott D; Mueller, John; Sriram, Shubha; Thresher, Jason; Walkup, Grant K.
Affiliation
  • Kern G; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451. Electronic address: gunther.kern@gmail.com.
  • Palmer T; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Ehmann DE; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Shapiro AB; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Andrews B; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Basarab GS; Departments of Chemistry, Infection Innovative Medicines Unit, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Doig P; Department of Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Fan J; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Gao N; Department of Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Mills SD; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Mueller J; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Sriram S; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Thresher J; Department of Structure and Biophysics, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
  • Walkup GK; Departments of Biosciences, Discovery Sciences, AstraZeneca R&D Boston, Waltham, Massachusetts 02451.
J Biol Chem ; 290(34): 20984-20994, 2015 Aug 21.
Article de En | MEDLINE | ID: mdl-26149691
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Spiranes / Barbituriques / ADN bactérien / DNA gyrase / DNA topoisomerase IV / Inhibiteurs de la topoisomérase-II / Antibactériens Limites: Humans Langue: En Journal: J Biol Chem Année: 2015 Type de document: Article Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Spiranes / Barbituriques / ADN bactérien / DNA gyrase / DNA topoisomerase IV / Inhibiteurs de la topoisomérase-II / Antibactériens Limites: Humans Langue: En Journal: J Biol Chem Année: 2015 Type de document: Article Pays de publication: États-Unis d'Amérique