Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion.

Tervonen, T A; Belitskin, D; Pant, S M; Englund, J I; Marques, E; Ala-Hongisto, H; Nevalaita, L; Sihto, H; Heikkilä, P; Leidenius, M; Hewitson, K; Ramachandra, M; Moilanen, A; Joensuu, H; Kovanen, P E; Poso, A; Klefström, J

Tervonen, T A; Belitskin, D; Pant, S M; Englund, J I; Marques, E; Ala-Hongisto, H; Nevalaita, L; Sihto, H; Heikkilä, P; Leidenius, M; Hewitson, K; Ramachandra, M; Moilanen, A; Joensuu, H; Kovanen, P E; Poso, A; Klefström, J.

Affiliation

Tervonen TA; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Belitskin D; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Pant SM; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Englund JI; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Marques E; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Ala-Hongisto H; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Nevalaita L; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.
Sihto H; Department of Oncology, University of Helsinki & Helsinki University Central Hospital, Helsinki, Finland.
Heikkilä P; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Leidenius M; Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland.
Hewitson K; Helsinki Innovation Services Ltd, Tukholmankatu 8A, 00290, University of Helsinki, Helsinki, Finland.
Ramachandra M; Aurigene Discovery Technologies Limited, 39-40 KIADB Industrial Area, Electronic City Phase II, Bangalore, India.
Moilanen A; Orion Corporation, Orion Pharma, Turku, Finland.
Joensuu H; Department of Oncology, University of Helsinki & Helsinki University Central Hospital, Helsinki, Finland.
Kovanen PE; Department of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Poso A; School of Pharmacy, University of Eastern Finland, Kuopio, Finland and Finnish Institute of Molecular Medicine, Helsinki, Finland.
Klefström J; Cancer Cell Circuitry Laboratory, Research Programs Unit, Translational Cancer Biology and Institute of Biomedicine, University of Helsinki, Helsinki, Finland.

Oncogene ; 35(14): 1832-46, 2016 Apr 07.

Article de En | MEDLINE | ID: mdl-26165838

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein / Serine endopeptidases / Facteur de croissance des hépatocytes / Protéines proto-oncogènes c-met / Protéines sécrétoires inhibitrices de protéinases Type d'étude: Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Oncogene Sujet du journal: BIOLOGIA MOLECULAR / NEOPLASIAS Année: 2016 Type de document: Article Pays d'affiliation: Finlande

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