Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice.

Etchin, J; Montero, J; Berezovskaya, A; Le, B T; Kentsis, A; Christie, A L; Conway, A S; Chen, W C; Reed, C; Mansour, M R; Ng, C E L; Adamia, S; Rodig, S J; Galinsky, I A; Stone, R M; Klebanov, B; Landesman, Y; Kauffman, M; Shacham, S; Kung, A L; Wang, J C Y; Letai, A; Look, A T

Etchin, J; Montero, J; Berezovskaya, A; Le, B T; Kentsis, A; Christie, A L; Conway, A S; Chen, W C; Reed, C; Mansour, M R; Ng, C E L; Adamia, S; Rodig, S J; Galinsky, I A; Stone, R M; Klebanov, B; Landesman, Y; Kauffman, M; Shacham, S; Kung, A L; Wang, J C Y; Letai, A; Look, A T.

Affiliation

Etchin J; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Montero J; Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA.
Berezovskaya A; Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA.
Le BT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Kentsis A; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Christie AL; Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Conway AS; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Chen WC; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Reed C; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Mansour MR; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Ng CE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Adamia S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Rodig SJ; Department of Haematology, UCL Cancer Institute, University College London, London, UK.
Galinsky IA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Division of Hematology/Oncology, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA.
Stone RM; Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA.
Klebanov B; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Landesman Y; Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA.
Kauffman M; Department of Medical Oncology, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA, USA.
Shacham S; Karyopharm Therapeutics, Natick, MA, USA.
Kung AL; Karyopharm Therapeutics, Natick, MA, USA.
Wang JC; Karyopharm Therapeutics, Natick, MA, USA.
Letai A; Karyopharm Therapeutics, Natick, MA, USA.
Look AT; Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center, New York, NY, USA.

Leukemia ; 30(1): 190-9, 2016 Jan.

Article de En | MEDLINE | ID: mdl-26202935

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Triazoles / Cellules souches tumorales / Leucémie aigüe myéloïde / Récepteurs cytoplasmiques et nucléaires / Caryophérines / Hydrazines Limites: Animals / Humans Langue: En Journal: Leukemia Sujet du journal: HEMATOLOGIA / NEOPLASIAS Année: 2016 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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