Origins, genetic landscape, and emerging therapies of small cell lung cancer.
Genes Dev
; 29(14): 1447-62, 2015 Jul 15.
Article
de En
| MEDLINE
| ID: mdl-26220992
ABSTRACT
Lung cancer is the leading cause of cancer deaths, with small cell lung cancer (SCLC) representing the most aggressive subtype. Standard treatments have not changed in decades, and the 5-year survival rate has remained <7%. Genomic analyses have identified key driver mutations of SCLC that were subsequently validated in animal models of SCLC. To provide better treatment options, a deeper understanding of the cellular and molecular mechanisms underlying SCLC initiation, progression, metastasis, and acquisition of resistance is required. In this review, we describe the genetic landscape of SCLC, features of the cell of origin, and targeted therapeutic approaches.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carcinome pulmonaire à petites cellules
/
Tumeurs du poumon
Limites:
Animals
/
Humans
Langue:
En
Journal:
Genes Dev
Sujet du journal:
BIOLOGIA MOLECULAR
Année:
2015
Type de document:
Article
Pays d'affiliation:
Pays-Bas