Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

Press, Neil J; Taylor, Roger J; Fullerton, Joseph D; Tranter, Pamela; McCarthy, Clive; Keller, Thomas H; Arnold, Nicola; Beer, David; Brown, Lyndon; Cheung, Robert; Christie, Julie; Denholm, Alastair; Haberthuer, Sandra; Hatto, Julia D I; Keenan, Mark; Mercer, Mark K; Oakman, Helen; Sahri, Helene; Tuffnell, Andrew R; Tweed, Morris; Trifilieff, Alexandre

Press, Neil J; Taylor, Roger J; Fullerton, Joseph D; Tranter, Pamela; McCarthy, Clive; Keller, Thomas H; Arnold, Nicola; Beer, David; Brown, Lyndon; Cheung, Robert; Christie, Julie; Denholm, Alastair; Haberthuer, Sandra; Hatto, Julia D I; Keenan, Mark; Mercer, Mark K; Oakman, Helen; Sahri, Helene; Tuffnell, Andrew R; Tweed, Morris; Trifilieff, Alexandre.

Affiliation

Press NJ; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Taylor RJ; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Fullerton JD; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Tranter P; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
McCarthy C; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Keller TH; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Arnold N; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Beer D; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Brown L; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Cheung R; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Christie J; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Denholm A; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Haberthuer S; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Hatto JD; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Keenan M; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Mercer MK; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Oakman H; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Sahri H; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Tuffnell AR; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Tweed M; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.
Trifilieff A; Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

J Med Chem ; 58(17): 6747-52, 2015 Sep 10.

Article de En | MEDLINE | ID: mdl-26288344

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Acides cyclohexanecarboxyliques / Broncho-pneumopathie chronique obstructive / Inhibiteurs de la phosphodiestérase-4 / Naphtyridines Limites: Animals / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2015 Type de document: Article Pays d'affiliation: Royaume-Uni

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