[GLIATILIN CORRECTION OF WORKING AND REFERENCE SPATIAL MEMORY IMPAIRMENT IN AGED RATS].
Eksp Klin Farmakol
; 78(6): 3-6, 2015.
Article
de Ru
| MEDLINE
| ID: mdl-26292506
ABSTRACT
This work was aimed at evaluating the influence of gliatilin administration on the spatial memory in aged rats. Cognitive function and spatial memory in animals was evaluated using radial (8-beam) maze test. Errors of working spatial memory and reference memory were used as indicators of impaired cognitive function. It was found that aged (24-month) rats compared with younger (6-months) age group exhibited cognitive impairment, as manifested by deterioration of short- and long-term memory processes. Course administration of gliatilin in rats of the older age group at a dose of 100 mg/kg resulted in significant improvement of the working and reference spatial memory in aged rats.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Vieillissement
/
Apprentissage du labyrinthe
/
Glycerylphosphorylcholine
/
Mémoire
/
Troubles de la mémoire
Limites:
Animals
Langue:
Ru
Journal:
Eksp Klin Farmakol
Sujet du journal:
FARMACOLOGIA
Année:
2015
Type de document:
Article