Emerging cytokine networks in colorectal cancer.
Nat Rev Immunol
; 15(10): 615-29, 2015 Oct.
Article
de En
| MEDLINE
| ID: mdl-26358393
ABSTRACT
Cytokine networks are crucial aspects of tumour immunology, particularly for colorectal cancer (CRC), in which inflammation and antitumour immunity are key determinants of disease progression. In this Review, we highlight new insights into the functions of well-known cytokines in CRC, describe recently discovered roles for a growing number of novel players, and emphasize the complexity and therapeutic implications of the cytokine milieu. We also discuss how cancer mutations and epigenetic adaptations influence the oncogenic potential of cytokines, a relatively unexplored area that could yield crucial insights into tumour immunology and facilitate the effective application of cytokine-modulatory therapies for CRC.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs colorectales
/
Transduction du signal
/
Cytokines
/
Médiateurs de l'inflammation
Limites:
Humans
Langue:
En
Journal:
Nat Rev Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2015
Type de document:
Article
Pays d'affiliation:
Royaume-Uni