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Reward-dependent modulation of working memory is associated with negative symptoms in schizophrenia.
Hager, Oliver M; Kirschner, Matthias; Bischof, Martin; Hartmann-Riemer, Matthias N; Kluge, Agne; Seifritz, Erich; Tobler, Philippe N; Kaiser, Stefan.
Affiliation
  • Hager OM; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Bluemlisalpstrasse 10, 8006 Zurich, Switzerland. Electr
  • Kirschner M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland.
  • Bischof M; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland.
  • Hartmann-Riemer MN; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Bluemlisalpstrasse 10, 8006 Zurich, Switzerland.
  • Kluge A; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland.
  • Seifritz E; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology, Wint
  • Tobler PN; Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, Bluemlisalpstrasse 10, 8006 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology, Wint
  • Kaiser S; Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Lenggstrasse 31, 8032 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Zurich Center for Integrative Human Physiology, Wint
Schizophr Res ; 168(1-2): 238-44, 2015 Oct.
Article de En | MEDLINE | ID: mdl-26362736
ABSTRACT
The negative symptoms of schizophrenia have been associated with altered neural activity during both reward processing and cognitive processing. Even though increasing evidence suggests a strong interaction between these two domains, it has not been studied in relation to negative symptoms. To elucidate neural mechanisms of the reward-cognition interaction, we applied a letter variant of the n-back working memory task and varied the financial incentives for performance. In the interaction contrast, we found a significantly activated cluster in the rostral anterior cingulate cortex (ACC), the middle frontal gyrus, and the bilateral superior frontal gyrus. The interaction did not differ significantly between the patient group and a healthy control group, suggesting that patients with schizophrenia are on average able to integrate reward information and utilize this information to maximize cognitive performance. However within the patient group, we found a significant inverse correlation of ACC activity with the factor diminished expression. This finding is consistent with the model that a lack of available cognitive resources leads to diminished expression. We therefore argue that patients with diminished expression have difficulties in recruiting additional cognitive resources (as implemented in the ACC) in response to an anticipated reward. Due to this lack of cognitive resources, less processing capacity is available for effective expression, resulting in diminished expressive behavior.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles psychotiques / Récompense / Schizophrénie / Encéphale / Mémoire à court terme Type d'étude: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans / Male Langue: En Journal: Schizophr Res Sujet du journal: PSIQUIATRIA Année: 2015 Type de document: Article

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles psychotiques / Récompense / Schizophrénie / Encéphale / Mémoire à court terme Type d'étude: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limites: Adult / Female / Humans / Male Langue: En Journal: Schizophr Res Sujet du journal: PSIQUIATRIA Année: 2015 Type de document: Article