Navigating CYP1A Induction and Arylhydrocarbon Receptor Agonism in Drug Discovery. A Case History with S1P1 Agonists.

Taylor, Simon J; Demont, Emmanuel H; Gray, James; Deeks, Nigel; Patel, Aarti; Nguyen, Dung; Taylor, Maxine; Hood, Steve; Watson, Robert J; Bit, Rino A; McClure, Fiona; Ashall, Holly; Witherington, Jason

Taylor, Simon J; Demont, Emmanuel H; Gray, James; Deeks, Nigel; Patel, Aarti; Nguyen, Dung; Taylor, Maxine; Hood, Steve; Watson, Robert J; Bit, Rino A; McClure, Fiona; Ashall, Holly; Witherington, Jason.

Affiliation

Taylor SJ; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
Demont EH; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
Gray J; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
Deeks N; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
Patel A; PTS DMPK, GlaxoSmithKline , Park Road, Ware, SG12 0DP, U.K.
Nguyen D; PTS DMPK, GlaxoSmithKline , Upper Merion, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
Taylor M; PTS DMPK, GlaxoSmithKline , Park Road, Ware, SG12 0DP, U.K.
Hood S; PTS DMPK, GlaxoSmithKline , Park Road, Ware, SG12 0DP, U.K.
Watson RJ; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
Bit RA; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.
McClure F; Safety Assessment, GlaxoSmithKline , Park Road, Ware, SG12 0DP, U.K.
Ashall H; Safety Assessment, GlaxoSmithKline , Park Road, Ware, SG12 0DP, U.K.
Witherington J; Immuno-Inflammation Therapy Area Unit, GlaxoSmithKline , Gunnels Wood Road, Stevenage, SG1 2NY, U.K.

J Med Chem ; 58(20): 8236-56, 2015 Oct 22.

Article de En | MEDLINE | ID: mdl-26393276

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Induction enzymatique / Récepteurs à hydrocarbure aromatique / Cytochrome P-450 CYP1A1 / Cytochrome P-450 CYP1A2 / Récepteurs aux lysosphingolipides Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2015 Type de document: Article Pays d'affiliation: Royaume-Uni Pays de publication: États-Unis d'Amérique

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