Molecular investigation of coexistent chronic myeloid leukaemia and peripheral T-cell lymphoma - a case report.
Sci Rep
; 5: 14829, 2015 Oct 06.
Article
de En
| MEDLINE
| ID: mdl-26439403
ABSTRACT
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm underlain by the formation of BCR-ABL1 - an aberrant tyrosine kinase - in the leukaemic blasts. Long-term survival rates in CML prior to the advent of tyrosine kinase inhibitors (TKIs) were dismal, albeit the incidence of secondary malignancies was higher than that of age-matched population. Current figures confirm the safety of TKIs with conflicting data concerning the increased risk of secondary tumours. We postulate that care has to be taken when distinguishing between coexisting, secondary-to-treatment and second in sequence, but independent tumourigenic events, in order to achieve an unbiased picture of the adverse effects of novel treatments. To illustrate this point, we present a case of a patient in which CML and peripheral T-cell lymphoma (PTCL) coexisted, although the clinical presentation of the latter followed the achievement of major molecular response of CML to TKIs.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Leucémie myéloïde chronique BCR-ABL positive
/
Lymphome T périphérique
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Sci Rep
Année:
2015
Type de document:
Article
Pays d'affiliation:
Italie