Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

Mertens, Jerome; Paquola, Apuã C M; Ku, Manching; Hatch, Emily; Böhnke, Lena; Ladjevardi, Shauheen; McGrath, Sean; Campbell, Benjamin; Lee, Hyungjun; Herdy, Joseph R; Gonçalves, J Tiago; Toda, Tomohisa; Kim, Yongsung; Winkler, Jürgen; Yao, Jun; Hetzer, Martin W; Gage, Fred H

Mertens, Jerome; Paquola, Apuã C M; Ku, Manching; Hatch, Emily; Böhnke, Lena; Ladjevardi, Shauheen; McGrath, Sean; Campbell, Benjamin; Lee, Hyungjun; Herdy, Joseph R; Gonçalves, J Tiago; Toda, Tomohisa; Kim, Yongsung; Winkler, Jürgen; Yao, Jun; Hetzer, Martin W; Gage, Fred H.

Affiliation

Mertens J; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Paquola ACM; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ku M; Next Generation Sequencing Core, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Hatch E; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Böhnke L; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ladjevardi S; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
McGrath S; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Campbell B; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Lee H; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Herdy JR; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Gonçalves JT; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Toda T; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Kim Y; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Winkler J; Department of Molecular Neurology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Yao J; State Key Laboratory of Membrane Biology, Tsinghua-Peking Joint Center for Life Sciences, McGovern Institute for Brain Research, School of Life Sciences, Tsinghua University, Beijing 100084, China.
Hetzer MW; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.

Cell Stem Cell ; 17(6): 705-718, 2015 Dec 03.

Article de En | MEDLINE | ID: mdl-26456686

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Vieillissement / Noyau de la cellule / Cytoplasme / Reprogrammation cellulaire / Cellules souches pluripotentes induites / Neurones Type d'étude: Prognostic_studies / Risk_factors_studies Limites: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Humans / Infant / Middle aged / Newborn Langue: En Journal: Cell Stem Cell Année: 2015 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google