Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism.

Stahl, Simone H; Yates, James W; Nicholls, Andrew W; Kenna, J Gerry; Coen, Muireann; Ortega, Fernando; Nicholson, Jeremy K; Wilson, Ian D

Stahl, Simone H; Yates, James W; Nicholls, Andrew W; Kenna, J Gerry; Coen, Muireann; Ortega, Fernando; Nicholson, Jeremy K; Wilson, Ian D.

Affiliation

Stahl SH; AstraZeneca, DMPK, Drug Safety and Metabolism, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
Yates JW; AstraZeneca, DMPK, Oncology Innovative Medicines, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
Nicholls AW; GlaxoSmithKline, Investigative Preclinical Toxicology, Park Road, Ware, Hertfordshire SG12 0DP, UK.
Kenna JG; FRAME, Russell & Burch House, North Sherwood Street, Nottingham NG1 4EE, UK.
Coen M; Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.
Ortega F; Centre for Applied Pharmacokinetic Research, Manchester Pharmacy School, The University of Manchester, Manchester M13 9PT, UK.
Nicholson JK; Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.
Wilson ID; Department of Surgery and Cancer, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK. Electronic address: i.wilson@imperial.ac.uk.

Drug Discov Today Technol ; 15: 9-14, 2015 Aug.

Article de En | MEDLINE | ID: mdl-26464084

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Glutathion / Acétaminophène / Modèles biologiques Type d'étude: Etiology_studies / Prognostic_studies Limites: Animals / Humans Langue: En Journal: Drug Discov Today Technol Année: 2015 Type de document: Article Pays d'affiliation: Royaume-Uni

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