Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients.
J Am Acad Dermatol
; 73(5 Suppl 1): S66-9, 2015 Nov.
Article
de En
| MEDLINE
| ID: mdl-26470620
ABSTRACT
Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Systèmes de délivrance de médicaments
/
Pyodermie phadégénique
/
Hidrosadénite suppurée
/
Acné juvénile
/
Antibactériens
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Am Acad Dermatol
Année:
2015
Type de document:
Article
Pays d'affiliation:
France