Lymphocyte/monocyte ratio in osteoarticular tuberculosis in children: a haematological biomarker revisited.
Trop Doct
; 46(2): 73-7, 2016 Apr.
Article
de En
| MEDLINE
| ID: mdl-26503639
ABSTRACT
INTRODUCTION:
*Work attributed to Department of Pediatric Orthopaedics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi-110031(India)This study tested the hypothesis whether the lymphocyte/monocyte ratio (L/M ratio) altered significantly during treatment of paediatric osteoarticular tuberculosis (OATB) for it to be a useful monitor of the response to therapy. MATERIAL ANDMETHODS:
Thirty immunocompetent paediatric patients with OATB treated with 6 months of uninterrupted multidrug anti-tubercular treatment with resultant clinical and radiological healing of the lesion were included. Haemoglobin, total leucocyte, monocyte and lymphocyte count, and erythrocyte sedimentation rate (ESR) were collected at 0, 2 and 6 months, and were analysed.RESULTS:
The L/M ratio altered from high (11) at the start of treatment towards normalisation (9) at 2 months and (7.7) at 6 months. There was no correlation with declining ESR levels.CONCLUSIONS:
The L/M ratio may have potential as an effective biomarker response.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tuberculose ostéoarticulaire
/
Lymphocytes
/
Monocytes
/
Marqueurs biologiques
Type d'étude:
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Trop Doct
Année:
2016
Type de document:
Article
Pays d'affiliation:
Inde