[Thrombotic thrombocytopenic purpura in a newborn]. / Purpura thrombotique thrombocytopénique chez un nouveau-né.
Arch Pediatr
; 23(1): 78-81, 2016 Jan.
Article
de Fr
| MEDLINE
| ID: mdl-26552625
ABSTRACT
We report the case of a newborn presenting with hemolytic anemia, thrombocytopenia, hyperbilirubinemia, and renal failure in the first hours of life. An early plasmatherapy was undertaken, with good outcome. The specific von Willebrand factor-cleaving protease activity (ADAMTS 13 for a disintegrin and metalloprotease with thrombospondin type 1 repeats) was found to be low. This is the specific biologic diagnostic element of congenital thrombotic thrombocytopenic purpura (TTP). This disease of constitutional thrombotic microangiopathy is rare. The prognosis, usually life-threatening, was completely transformed given the better understanding of the pathogenesis of the disease and therapeutic progress.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Purpura thrombotique thrombocytopénique
Type d'étude:
Etiology_studies
/
Prognostic_studies
Limites:
Humans
/
Male
/
Newborn
Langue:
Fr
Journal:
Arch Pediatr
Année:
2016
Type de document:
Article