Toward a synthesis of developmental biology with evolutionary theory and ecology.
Annu Rev Cell Dev Biol
; 31: 453-71, 2015.
Article
de En
| MEDLINE
| ID: mdl-26566116
ABSTRACT
The evolutionary conservation of developmental mechanisms is a truism in biology, but few attempts have been made to integrate development with evolutionary theory and ecology. To work toward such a synthesis, we summarize studies in the nematode model Pristionchus pacificus, focusing on the development of the dauer, a stress-resistant, alternative larval stage. Integrative approaches combining molecular and genetic principles of development with natural variation and ecological studies in wild populations have identified a key role for a developmental switch mechanism in dauer development and evolution, one that involves the nuclear hormone receptor DAF-12. DAF-12 is a crucial regulator and convergence point for different signaling inputs, and its function is conserved among free-living and parasitic nematodes. Furthermore, DAF-12 is the target of regulatory loops that rely on novel or fast-evolving components to control the intraspecific competition of dauer larvae. We propose developmental switches as paradigms for understanding the integration of development, evolution, and ecology at the molecular level.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Récepteurs cytoplasmiques et nucléaires
/
Régulation de l'expression des gènes au cours du développement
Limites:
Animals
/
Humans
Langue:
En
Journal:
Annu Rev Cell Dev Biol
Sujet du journal:
BIOLOGIA
Année:
2015
Type de document:
Article