Cortical Flow-Driven Shapes of Nonadherent Cells.
Phys Rev Lett
; 116(2): 028102, 2016 Jan 15.
Article
de En
| MEDLINE
| ID: mdl-26824569
ABSTRACT
Nonadherent polarized cells have been observed to have a pearlike, elongated shape. Using a minimal model that describes the cell cortex as a thin layer of contractile active gel, we show that the anisotropy of active stresses, controlled by cortical viscosity and filament ordering, can account for this morphology. The predicted shapes can be determined from the flow pattern only; they prove to be independent of the mechanism at the origin of the cortical flow, and are only weakly sensitive to the cytoplasmic rheology. In the case of actin flows resulting from a contractile instability, we propose a phase diagram of three-dimensional cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate shapes, all of which have been observed in experiment.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cytoplasme
/
Forme de la cellule
/
Modèles biologiques
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Phys Rev Lett
Année:
2016
Type de document:
Article
Pays d'affiliation:
France