Protein-lipid interactions critical to replication of the influenza A virus.
FEBS Lett
; 590(13): 1940-54, 2016 07.
Article
de En
| MEDLINE
| ID: mdl-26921878
ABSTRACT
Influenza A virus (IAV) assembles on the plasma membrane where viral proteins localize to form a bud encompassing the viral genome, which ultimately pinches off to give rise to newly formed infectious virions. Upon entry, the virus faces the opposite task-fusion with the endosomal membrane and disassembly to deliver the viral genome to the cytoplasm. There are at least four influenza proteins-hemagglutinin (HA), neuraminidase (NA), matrix 1 protein (M1), and the M2 ion channel-that are known to directly interact with the cellular membrane and modify membrane curvature in order to both assemble and disassemble membrane-enveloped virions. Here, we summarize and discuss current knowledge of the interactions of lipids and membrane proteins involved in the IAV replication cycle.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus de la grippe A
/
Protéines virales
/
Réplication virale
/
Métabolisme lipidique
Langue:
En
Journal:
FEBS Lett
Année:
2016
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique