MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.
Nature
; 531(7593): 237-40, 2016 Mar 10.
Article
de En
| MEDLINE
| ID: mdl-26934225
ABSTRACT
Identifying key molecules that launch regeneration has been a long-sought goal. Multiple regenerative animals show an initial wound-associated proliferative response that transits into sustained proliferation if a considerable portion of the body part has been removed. In the axolotl, appendage amputation initiates a round of wound-associated cell cycle induction followed by continued proliferation that is dependent on nerve-derived signals. A wound-associated molecule that triggers the initial proliferative response to launch regeneration has remained obscure. Here, using an expression cloning strategy followed by in vivo gain- and loss-of-function assays, we identified axolotl MARCKS-like protein (MLP) as an extracellularly released factor that induces the initial cell cycle response during axolotl appendage regeneration. The identification of a regeneration-initiating molecule opens the possibility of understanding how to elicit regeneration in other animals.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Régénération
/
Protéines et peptides de signalisation intracellulaire
/
Membres
/
Ambystoma mexicanum
/
Protéines membranaires
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Nature
Année:
2016
Type de document:
Article
Pays d'affiliation:
Allemagne