EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn.
Influenza Other Respir Viruses
; 10(3): 154-60, 2016 May.
Article
de En
| MEDLINE
| ID: mdl-26935868
ABSTRACT
BACKGROUND:
Human enterovirus D68 (EV-D68) recently caused an increase in mild-to-severe pediatric respiratory cases in North America and some European countries. Even though few of these children presented with acute paralytic disease, direct causal relationship cannot yet be assumed.OBJECTIVES:
The purposes of this report were to describe the clinical findings of an outbreak of EV-D68 infection in Mexico City and identify the genetic relationship with previously reported strains. PATIENTS/METHODS:
Between September and December 2014, 126 nasopharyngeal samples (NPS) of hospitalized children <15 years of age with ARI were tested for the presence of respiratory viruses using a multiplex RT-qPCR and EV-D68-specific RT-qPCR. Clinical, epidemiological, and demographic data were collected and associated with symptomatology and viral infections. Phylogenetic analyses were performed using VP1 region.RESULTS:
Enterovirus/rhinovirus infection was detected in 40 patients (31·7%), of which 24 patients were EV-D68-positive. EV-D68 infection prevailed over September and October 2014 and was associated with neutrophilia and lymphopenia, and patients were more likely to develop hypoxemia. Phylogenetic analyses showed that Mexican EV-D68 belongs to the new B1 clade.CONCLUSIONS:
This is the first EV-D68 outbreak described in Mexico and occurred few weeks after the United States reported similar infections. Although EV-D68 belongs to new B1 clade, no neurological affection was observed.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pneumopathie virale
/
Infections de l'appareil respiratoire
/
Asthme
/
Entérovirus humain D
/
Infections à entérovirus
Type d'étude:
Prognostic_studies
Limites:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Pays/Région comme sujet:
Asia
/
Europa
/
Mexico
Langue:
En
Journal:
Influenza Other Respir Viruses
Sujet du journal:
VIROLOGIA
Année:
2016
Type de document:
Article
Pays d'affiliation:
Mexique